The Emergence of Mupirocin Resistance among Staphylococcus aureus in a Tertiary Care Hospital in South India: The Necessity for Routine Susceptibility Testing

Methicillin-resistant Staphylococcus aureus (MRSA) is difficult to treat, causing considerable morbidity and mortality. Nasal carriage of MRSA can occur both in healthcare workers patients. Mupirocin used as a topical agent for the eradication such isolates. The present study aims prevalence mupirocin resistance among MSSA (Methicillin-sensitive aureus) A total 148 isolates were tested. Antibiotic susceptibility testing was done by Kirby Bauer disc diffusion method amoxicillin, penicillin, cotrimoxazole, clindamycin, mupirocin(5 µg 200 discs low high-level resistance), erythromycin, gentamicin linezolid. detected cefoxitin Mec detection PCR (Polymerase Chain Reaction). 44 (29.7%) Among MSSA, good observed cotrimoxazole 89 (85.5%) clindamycin 92 (88.4%). An overall 12(8.1%) observed, with at 4 (2.7%) low-level 8 (5.4%).The pattern between not statistically significant (p=0.1833). emergence highlights necessity creating cognizance clinicians before prescribing mupirocin. In eradicating nasal MRSA, all should always be tested prevent selection spread drug-resistant